Influence of Isoflurane on the Integrity of the Blood Brain Barrier in Rats
Abstract
Treatment of massive orthopedic and soft tissue trauma has evolved over the last 15 years of military conflicts. Damage control surgery, or repeated brief surgical exposures has become standard practice. Each of these brief operations requires exposure to some form of anesthesia, usually with a volatile anesthetic. Prolonged exposure to anesthesia has been shown to cause alterations in the structure and function of the blood brain barrier (BBB). The effects of multiple brief exposures to isoflurane on the structure and function of the BBB have not yet been studied.The objective of this proposal is to evaluate the expression and location of tight junction proteins as well as the permeability of BBB following multiple brief exposures to isoflurane.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU0001151TS15
Entities
People
- John Litchfield
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences