Iron Activation of Cellular Oxidases: Modulation of Neuronal Viability (In Vitro)
Abstract
Iron contributes to oxidative stress in a number of conditions. The reactive oxygen species (ROS) generated by iron can activate the NADPH oxidase (NOX) enzymes, which are expressed predominantly in microglia in the brain and contribute to activation of pro-inflammatory pathways and the production of even more ROS. This feed forward paradigm may explain chronic pro-inflammatory polarization of microglia following traumatic brain or spinal cord injury. Currently no research has explored the relationship between iron and NOX. Therefore we hypothesize that exogenous iron stimulates NOX to generate ROS, perpetuating a pro-inflammatory phenotype in microglia that diminishes neuronal viability in vitro.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU0001151TS16
Entities
People
- Young Yauger
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences