Study of Epinephrine Resuscitation in a Swine Hypovolemic Cardiac Arrest Model
Abstract
This study will determine the effects and pharmakinetics of administration of epinephrine by bone (intraosseous (IO)), by vein (intravenous (IV)), and by endotracheal (EO) routes in a shock or hypovolemic (low blood volume) model of cardiac arrest. Yorkshire Cross Swine will be used for this study, which will contain 7 groups, each with 7 swine. The seven groups will consist of CPR only, CPR with defibrillation, IV epinephrine (EPI), Sternal IO (EPI), Tibia 10 (EPI), Humerus IO (EPI) and Endotracheal (double dose EPI). In summary, all swine will be sedated, anesthetized, and placed on mechanical ventilation with appropriate monitors applied. It is generally thought that IO administration is equivalent to IV administration, as IO infusions have been used in military casualties including hemorrhage, traumatic injury, dehydration, cardiovascular collapse, and burns. This study will produce the data that are needed to determine if dose alterations are warranted when administering epinephrine through an IO catheter in a cardiac arrest, hypovolemic model. The implications of the findings of this study can be applied in any military or civilian facility where patients may have cardiacarrest with hemorraghic shock.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU0001161TS04
Entities
People
- Joseph O Sullivan
Organizations
- Geneva Foundation
- Uniformed Services University of the Health Sciences