Pilot Validation of Hemodilution Technique to Estimate Blood Volume in Vivo
Abstract
The primary goal of perioperative fluid therapy is to optimize patient total blood volume (TBV) for a given degree of cardiac function and thereby promote adequate end organ tissue perfusion. Commonly used methods to assess perioperative TBV and manage intravenous (IV) fluids are insensitive and nonspecific for identifying TBV abnormalities. There is strong evidence from the civilian anesthesia and surgical literature that the use of indicators of cardiac output as markers of TBV to guide fluid therapy (Goal Directed Fluid Therapy, or GDFT), leads to significantly better patient outcomes. However, current GDFT relies heavily on technology not feasible for use in the military field setting. Therefore, the primary objective of this study is to assess the accuracy of determining a patient’s TBV using military relevant point-of-care measurement of red blood cell volume (hematocrit, or HCT) before and after hemodilution with a standard IV solution.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU0001161TS14
Entities
People
- Kenneth Wofford
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences