Investigation of a Translatable Animal Model in Order to Understand the Etiology of Heterotopic Ossification
Abstract
Heterotopic ossification, HO, refers to ectopic bone formation, typically in residual limbs and/or peri-articular regions following trauma and injury. This pathological process manifests outside of the skeleton and is comprised of a hybrid of cortical and cancellous bone. HO was first reported by El Zahrawi, Albucasis, in 1000 C.E. in which he noted that stony hard prominences occasionally developed during fracture healing and demanded urgent removal. While the etiology of HO has not been elucidated in the nearly 1100 years since its initial observance, there has been a general agreement in the orthopedic literature that HO is induced from damage to soft tissue and inflammation, ectopic bone growth has been most frequently observed after combat-related trauma to service members with blast injuries.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU00011710047
Entities
People
- Dustin L Williams
Organizations
- Uniformed Services University of the Health Sciences
- University of Utah