Prolonged Intranasal Delivery of Ketamine Using Mucoadhesive Particles
Abstract
The objective of the proposed work is to develop an intranasal sustained release delivery formulation for Ketamine in order to treat post-traumatic stress disorder (PTSD). We will synthesize Ketamine-loaded nanoparticles, develop and optimize models for intranasal delivery of nanoparticles, characterize their degradation kinetics and mucoadhesive properties, and evaluate their safety and pharmacokinetics in a rat model. An additional goal of this proposal is to strengthen collaborations between faculty and students at BU and USU. To ensure this, we will establish a Visiting Scholars program for USU faculty rotations, during which USU faculty members will reside at BU for up to eight weeks at a time. These rotations will provide USU faculty with the opportunity to engage in a range of activities with the goal of enhancing research, professional development, and ongoing BU/USU collaborations.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 18, 2018
- Source ID
- HU00011810012
Entities
People
- Mark W Grinstaff
Organizations
- Boston University
- Uniformed Services University of the Health Sciences