Life Sciences (Basic Research)
Abstract
This project (LF1) focuses on fundamental efforts to understand living systems' responses to biological or chemical agents, to support detection, protection, diagnostics, and medical treatment. Research focuses on studying factors which influence the behavior of chemicals, toxins, and pathogens in relation to the host or target. Understanding of host/agent interactions can drive exploration of novel approaches to detect, diagnose or protect against threats. Research also focuses on medical countermeasures for improved efficacy against a wide array of current and future threat agents. This project is a key enabler supporting the Mitigate, Protect, and Understand portfolios. Individual efforts in this Project include: -Research to understand threats focused on illuminating pathogen/host interactions, innate and targeted immune responses, and drug/pathogen interactions that enable development of new medical countermeasures and diagnostic platforms. -Research in advancing countermeasures to understand underpinnings necessary to advance translational animal models for human disease, to explore artificial intelligence/machine learning (AI/ML) and novel structural biology approaches for enhancing rapid medical defense capabilities, to seek platform technologies with broad flexibility for drug development, and to improve protective factors for increasing therapeutic efficacy.
Document Details
- Document Type
- Project
- Publication Date
- Oct 01, 2023
- Source ID
- LF1_0601384BP_1_0400_PB_2023
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