MEDICAL CHEMICAL DEFENSE (ACD&P)
Abstract
This Project provides for the development of medical materiel and other medical equipment items necessary for the Technology Development phase of the acquisition life cycle for the advanced development of medical countermeasures (MCMs) for chemical agents including diagnostic equipment, prophylactic, pre-treatment, and therapeutic drugs, and individual/casualty decontamination compounds. A family-of-systems approach for medical defense against chemical agents is required to provide protection, to sustain performance in a chemical environment, and to provide for self-aid/buddy-aid and medical treatment of chemical casualties. Fielding of prophylactic, pre-treatment, and therapeutic drugs and medical devices requires Food and Drug Administration (FDA) approval. Given the family-of-systems approach for development of chemical MCMs for the treatment of nerve agent intoxication, multiple long-term studies are required to obtain FDA approval to deliver products that effectively integrate with current and projected therapeutic regimens. Efficacy testing of most candidate drugs against chemical warfare agents cannot be conducted in humans; therefore, animal surrogate models must be developed and employed. The program currently funds: (1) Bioscavenger, a new capability, to be used as a prophylaxis against nerve agents; (2) Centrally Acting Nerve Agent Treatment System (CANATS), an adjunct that augments the current capability, will treat adverse effects of nerve agent intoxication occurring in the central nervous system and will provide improved survival, reduced morbidity, and decreased neurological damage; and (3) Improved Nerve Agent Treatment System (INATS), a replacement and improvement to existing capability, to be used as a treatment for nerve agent intoxication; the INATS effort also includes expanding the indications for Pyridostigmine Bromide (PB) that will be integrated with current therapeutic regimens. The INATS program efforts do not continue beyond FY12. CANATS advanced development efforts have been delayed beyond FY13.
Document Details
- Document Type
- Project
- Publication Date
- Oct 01, 2013
- Source ID
- MC4_0603884BP_4_0400_PB_2013
Related Documents
- Root: CHEMICAL/BIOLOGICAL DEFENSE (ACD&P)
- Child Accomplishment: 1) BSCAV
- Child Accomplishment: 2) CANATS
- Child Accomplishment: 3) INATS
- Child Accomplishment: 4) INATS
- Child Accomplishment: 5) INATS
- Child Accomplishment: 6) INATS
- Child Accomplishment: 7) SBIR
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