Medical Chemical Defense (ACD&P)
Abstract
This Project provides for the development of medical materiel and other medical equipment items necessary for the Technology Maturation and Risk Reduction phase of the acquisition life cycle for the advanced development of Medical Countermeasures (MCMs) for chemical warfare agents including diagnostic equipment, prophylactic, pre-treatment, and therapeutic drugs, and individual/casualty decontamination compounds. A family-of-systems approach for medical defense against chemical warfare agents is required to provide protection, to sustain performance in a chemical environment, and to provide for self-aid/buddy-aid and medical treatment of chemical casualties. Fielding of prophylactic, pre-treatment, and therapeutic drugs and medical devices requires Food and Drug Administration (FDA) approval. Given the family-of-systems approach for development of chemical MCMs for the treatment of nerve agent intoxication, multiple long-term studies are required to obtain FDA approval to deliver products that effectively integrate with current and projected therapeutic regimens. Efficacy testing of most candidate drugs against chemical warfare agents cannot be conducted in humans; therefore, animal surrogate models must be developed and employed. Efforts included in this project are: (1) Emerging Threats (EMRT) (2) Improved Nerve Agent Treatment System (INATS) EMRT program is developing and fielding of FDA-approved therapeutic medical countermeasures (MCMs). The purpose of the MCM is to provide therapeutic benefits to the Joint Service warfighter against operational exposures to the opioid class of pharmaceutical-based agents (PBAs) as a high priority. The EMRT program is called the Rapid Opioid Countermeasure System (ROCS) in FY20 MC5. ROCS will use MC5 funds for advanced development of a 10 mg naloxone autoinjector as a rescue therapeutic to treat against operational opioid exposure. The INATS advanced development provides an enhanced capability treatment regimen offering greater protection over a broader spectrum of toxic nerve agent threats. Components of the development include (1) a new and improved oxime (replacing 2-pralidoxime chloride (2-PAM) to treat current and emerging threats and (2) insertion of a centrally-acting (CA) anticholinergic agent to the treatment regimen to increase survivability and decrease morbidity. The INATS treatment regimen both improves the performance of, and eventually replaces the Antidote Treatment Nerve Agent Auto-injector (ATNAA).
Document Details
- Document Type
- Project
- Publication Date
- Oct 01, 2021
- Source ID
- MC4_0603884BP_4_0400_PB_2021
Related Documents
- Root: CHEMICAL/BIOLOGICAL DEFENSE (ACD&P)
- Child Accomplishment: 1) Emerging Threats (EMRT) - Prototype Development
- Child Accomplishment: 2) Improved Nerve Agent Treatment System (INATS)
- Child Accomplishment: 3) INATS
- Child Accomplishment: 4) INATS
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