Characterization and Treatment of Metabolic Syndrome and Iron Overload in Navy Bottlenose Dolphins
Abstract
ONR Technical Proposal – Project Summary BAA 15-001 Title of Proposal: Characterization and Treatment of Metabolic Syndrome and Iron Overload in Navy Bottlenose Dolphins Prime Offeror: National Marine Mammal Foundation A series of studies by the NMMF over recent years have demonstrated that Navy dolphins are susceptible to metabolic syndrome and associated iron overload. These chronic, sub-clinical conditions may increase their susceptibility to other disease complications and decrease their health span. As such, there is a need to understand potential complications that may be associated with metabolic syndrome and iron overload, including renal and cardiovascular disease; and the presence underlying oxidative stress that may have long-term effects on organ function. Initial examination of the Navy dolphin diet has revealed potential fish-based nutrients that, when increased or decreased appropriately to mimic levels in the wild dolphin diet, may help protect dolphins against metabolic syndrome and iron overload. Early feeding studies with six dolphins have demonstrated encouraging results. We propose assessment of potential cardiovascular, renal, and oxidative stress-associated complications of metabolic syndrome and iron overload in the Navy dolphin population; and expansion of refined dietary trials with the goal of preventing and reversing iron overload, metabolic syndrome, and identified complications in Navy dolphins.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N000141512131
Entities
People
- Stephanie Venn-Watson
Organizations
- National Marine Mammal Foundation
- Office of Naval Research
- United States Navy