Peritoneal Microbubble Oxygen Treatment of DCS
Abstract
PERITONEAL MICROBUBBLE OXYGENATION TREATMENT OF DCS The reliance on hyperbaric therapy to treat decompression sickness (DCS) requires large hyperbaric chambers and expertise. As such, operational logistics and/or unanticipated events may leave divers or trapped submariners with inadequate resources for DCS therapy or prevention. Novel methods to treat or prevent DCS without the use of a hyperbaric chamber will greatly improve diver safety and disabled submarine rescue/escape as well as expand mission capabilities by removing the logistical burden of chamber availability with remote operations. The main objective of this research is to develop and test peritoneal microbubble oxygenation technology as a non-recompressive rescue therapy for DCS. The delivery of phospholipid-coated oxygen microbubbles intra-peritoneally may present a minimally invasive, preventative and therapeutic strategy against DCS by enhancing inert gas elimination and oxygen delivery. The first aim of the research will determine nitrogen washout curves in rats following peritoneal delivery of oxygen microbubbles. The second aim of the research will test peritoneal microbubble oxygenation therapy in a rat model for DCS and prepare the technology for future large-animal studies. Successful completion of these aims will provide the necessary validation for further translational studies of peritoneal microbubble oxygenation therapy for DCS.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N000141512274
Entities
People
- Mark A. Borden
Organizations
- Office of Naval Research
- Regents of the University of Colorado
- United States Navy