Molecular indicators of chronic stress ina model pinniped - the northern elephant seal
Abstract
Limited data are currently available on molecular mechanisms that mediate the stress response in marine mammals. This insufficiency hinders discovery and development of markers of elevated stress and its consequences. Non-targeted "-omics" technologies offer a powerful approach for rapidly increasing our understanding of the stress response. Transcriptomics quantifies global changes in gene activity during a physiological perturbation; metabolomics quantifies global changes in metabolic products between distinct phenotypic states (Wang et al., 2009; Patti et al., 2012). Genes and metabolic pathways that are significantly altered between baseline and stressed conditions can be used as qualitative and quantitative markers of physiological stress. The objectives of the proposed effort are to determine molecular markers of stress using (1) transcriptomics and (2) metabolomics approaches, (3) integrate these molecular markers to discover commonalities, and (4) use these integrated markers to distinguish acute and chronic stress states in marine mammals.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N000141512773
Entities
People
- Cory D Champagne
Organizations
- National Marine Mammal Foundation
- Office of Naval Research
- United States Navy