The microbiome and responsiveness to stress: Countermeasure strategies for improving resilience to sleep and circadian disruption
Abstract
Emerging evidence indicates that the gut microbiota influences human physiology and behavior with important implications for health, cognitive and affective function, and responses to stress. However, which specific microbes or microbial community structure are associated with positive and negative physiological and behavioral host responses to stress are largely unknown. Increased understanding of the microbiota’s role in stress responses and of microbiota-host interactions via the microbiota-gut-brain axis is important for development of effective countermeasure strategies to improve stress robustness during military ops. Sleep deprivation and circadian misalignment are common in military ops and effective countermeasure strategies are critical to increase stress robustness and for our warfighters to maintain operational dominance under such conditions. This project will test animal (rodent) and human subjects during sleep deprivation and circadian misalignment while characterizing the role the microbiome-gut-brain-axis plays in behavioral and cognitive responses to these stressors. If successful the studies will significantly advance understanding of the interaction between the microbiota, chronobiology and stress responses, and help with the development and future deployment of stress countermeasures
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N000141512809
Entities
People
- Kenneth P. Wright
Organizations
- Office of Naval Research
- Regents of the University of Colorado
- United States Navy