DURIP: Enhancing Capability of Quantitative Biology Research and Education
Abstract
DURIP: Enhancing capability of quantitative biology research and education Lingchong You, PhD Department of Biomedical Engineering Center for Genomic and Computational Biology Duke University Abstract A major goal of synthetic biology is to develop the ability to program complex dynamics in a predictable manner in single cells and cell populations. These engineered systems can allow us to develop in-depth understanding of the design principles underlying the operation of biological systems. Further, they can serve as the foundation for developing novel technologies. Toward this goal, a major challenge is to develop the capability to design, manipulate, and quantitatively measure biological parts and devices, and cell populations in a high-throughput manner. To this end, we propose to enhance the capability of quantitative-biology research related to ongoing projects funded by different DOD agencies, particularly ONR and ARO. Specifically, we propose to request funds to enhance the infrastructure for high-throughput manipulation and measurements of bacterial populations, in terms of growth dynamics and gene expression. These include a Tecan EVO robotic system for automated operation of microplate readers and a BUCHI encapsulator. The Tecan robotic system will greatly improve the throughput of bacterial culturing and measurements. The BUCHI encapsulator will allow us to use encapsulation as an approach to manipulate small bacterial populations. In addition to enhancing research in these ongoing DOD projects, the proposed instruments will also enhance related research funded by other agencies, including NSF and NIH, as well as other researchers at Duke funded by DOD. Furthermore, these instruments will enhance training experience of students and postdocs participating in DOD-funded research by exposing them to cutting-edge technologies that are not yet readily available at Duke.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Aug 12, 2016
- Source ID
- N000141512828
Entities
People
- Lingchong You
Organizations
- Duke University
- Office of Naval Research
- United States Navy