A Wireless Neural Recording System for the Study of Memory Consolidation in Naturalistic Environments
Abstract
ABSTRACT: DR. T MCKENNA, CIV ONR 341 This proposal is to request funds for a new Neuralynx wireless data acquisition system. This system was put on the market in November 2014 and will support and greatly improve the work proposed in our 2013 MURI award (N000141310672, PIs: Bazhenov, Cash, Fellous, Halgren, Rulkov and Sejnowski). This system will allow for untethered recordings from the rodent brain in large, complex and realistic environments that include obstacles and rich 3D features. This type of environment will challenge the spatial navigation system of the animal, especially its memory system. As such, the processes of memory consolidation during sleep are expected to be of much greater relevance to the behavior of the animal than in the cue-poor environments which were originally proposed because of the technical limitation of a physical tether. This wireless system will also allow for the use of a much larger arena in which different spatial scales can be manipulated. Larger spatial scales have been known in recent years to recruit different subsets of neurons in the spatial navigation system. How these different spatial scales contribute to spatial memory consolidation is to this day unknown. The wireless system will therefore uniquely enable the study of the consolidation of multi-scale spatial representations during sleep. Finally, the portability of the wireless system will allow for the recording of the animal in multiple rooms and environments, including the colony room. Such diversity will allow for the study of the changes in the spatial coding (remapping) of the same neurons in large number of environments (so far limited to 2 or 3). This system will be used to educate the research team and collaborators in the use of wireless neural recording technologies, with an eye on application to Human intracranial recordings.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 22, 2016
- Source ID
- N000141512838
Entities
People
- Jean-Marc Fellous
Organizations
- Office of Naval Research
- United States Navy
- University of Arizona