Aperio ScanScope FL as a tool for Research on Perfluorocarbons as a Vehicle for Intrapulmonary Administration of Drugs
Abstract
The ability to visualize biological tissues, cells, and subcellular organelles has undergone monumental advancessince the 1676 discovery of the red blood cell by Antonie van Leeuwenhoek using one of the earliest microscopes. Later, development of antibodies allowed immunodetection of specific proteins and discovery of fluorescence allowed for vivid localization of multiple proteins within a multitude of subcellular compartmentsand organelles. Despite that modern microscopy techniques deliver impressive cellular detail, the current imaging methods suffer from being time-intensive, highly variable, and archiving of the resulting images is cumbersome at best. Dr. David Irwin is exploring a novel method for safe and effective delivery of therapeuticcompounds using "nano-carriers" into lungs for treatment of cardiopulmonary conditions relevant to the mission of the Department of Defense (DoD) and the mission of the Office of Naval Research (ONR), a projectthat is currently funded by the DoD ("Inhibiting the hypoxic pulmonary vasoconstrictive (HPV) responses byutilizing perfluorocarbon as novel intrapulmonary drug delivery agents).
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 26, 2018
- Source ID
- N000141612038
Entities
People
- David Irwin
Organizations
- Office of Naval Research
- Regents of the University of Colorado
- United States Navy