THIS GRANT IS A CONTINUATION OF N000141410538 Coupling of Metabolic and Mechanical Function in Cell Physiology
Abstract
Identify the molecular basis of pathophysiological mitochondrial responses to environmental stressors as the bioenergetic basis of cell dysfunction to enable therapeutic insights and facilitate the development of cytoprotective interventions to reduce cell and tissue injury resulting from such stressors. The research pursues three aims. 1) Establish baseline bioenergetic profiles and correlate mitochondrial and mechanical dysfunction under controlled pathological conditions; 2) Quantify effects of controlled alterations in cellular mechanical integrity on mitochondrial function; 3) Quantify the effects of mitochondrial inhibitors on mechanical function. Results of this work will provide fundamental insights into molecularmechanical- bioenergetic coupling in cellular metabolic engineering under environmental stress and facilitate the development of cytoprotective interventions to reduce cell and tissue injury resulting from such stressors.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 10, 2016
- Source ID
- N000141612100
Entities
People
- David M Eckmann
Organizations
- Office of Naval Research
- United States Navy
- University of Pennsylvania