Enhancement of Osseointegration through Intervention of Cell Signaling Network
Abstract
SW-1603: Monitoring Osseo Integrated Prostheses (MOIP)Enhancement of Osseointegration through Intervention of Cell Signaling NetworkTranscutaneous prosthetic implants, compared to traditional socket prosthetics, often suffer a higher rate of failure due to marsupilisation, avulsion, and infection. The primary reason can be attributed to insufficient seal between the implant and the epidermis resulting from poor skin and soft tissue attachment to the implant. Skin and soft tissue attachment to the implant is mediated likely by a complex cell signaling network that alsomediates the cell-matrix adhesion during cell proliferation, migration, and development. Understanding how cell signaling network collectively regulates the dynamic process of cell adhesion will lead to the development of new strategies for enhancingosseointegration through strengthening the adhesion between soft bone/tissue/skin and implants. We propose to establish a technical platform that consists of a combination of QCM-D and AFM-based nano robot for in vitro examination of cell adhesion on the implant surface. We will utilize this platform to explore the feasibility of employing electrical stimulation, pharmacological intervention, and genetic intervention formanipulating cell adhesion. Based on the experimental data, we will construct a preliminary computational model that is capable of providing mechanistic insight into the regulation of cell adhesion on the implant surface.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 23, 2016
- Source ID
- N000141612626
Entities
People
- Jun Xi
Organizations
- Drexel University
- Office of Naval Research
- United States Navy