REPROGRAMMED COCHLEAR RESILIENCE TO INFLAMMATION AND APOPTOSIS
Abstract
A major limitation in the efficient delivery of protective drugs to the cochlea is the blood brain barrier that extensively filters blood to the stria vascularis and prohibits the delivery of drugs in significant amounts to prevent or treat Noise Induced Hearing Loss (NIHL). In this project, the investigator will evaluate the protective effect of exosome-mediated payload delivery of engineered miRNA and other engineered compounds to cochlear cells undergoing inflammation stress leading to apoptosis. The aim of this research is to achieve a non-toxic, enabling treatment strategy suitable to cross the blood brain barrier to protect and increase the endurance of the cochlea against NIHL experienced by military personnel. The PI will attempt to identify the exosome-responsive molecular and biochemical mechanisms underlying the early response to toxic noise exposure and prevent inflammation leading to animal studies and benefit in humans.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 23, 2016
- Source ID
- N000141612744
Entities
People
- Rick Rogers
Organizations
- Office of Naval Research
- President and Fellows of Harvard College
- United States Navy