Memory Consolidation During sleep in Humans, Rodents and Computational Models
Abstract
The goal of the proposed research is to develop techniques with the potential for an orders of magnitudeimprovement in spatial scale measured neuronal activity in patients undergoing surgical resection of brain lesion, such as temporal lobectomy, for epilepsy refractory to medical therapy. I have extensive experience in the functional neurosurgery over 10 years at UCSD. I am an active number of both our epilepsy and movementdisorder teams. These are multi-modality teams that have joint clinics and team meetings to evaluate patient sand treatments. I see more than 50 clinic patient s a month and we surgically treat approximately 75 patients a year in the functional neurosurgery program associated with the epilepsy and deep brain stimulation program. I have a broad background in clinical trials. I ran a trial in the immunologic therapy for brain tumors as a research fellow at the National Institute of Health. I completed a phase I trial of nerve growth factor genetherapy for Alzheimer s disease and served as a co investigator in a multi-center phase II trial of the samestudy. I am currently collaborating with Prof. Eric Halgren in an IRB approved study of neuronal activityassociated with language in awake patients undergoing temporal lobectomy for epilepsy. The proposed studiesin patients undergoing epilepsy surgery and deep brain stimulation surgery will be done in collaboration withProf Halgren. We anticipate in the future that this research model will refine minimally invasive recordingtechniques for the human brain that can be used to guide neurosurgical procedures and to accelerate humanneuroscience research.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 23, 2016
- Source ID
- N000141612829
Entities
People
- Maksim Bazhenov
Organizations
- Office of Naval Research
- United States Navy
- University of California, San Diego