Cochlear Synaptopathy and Neurodegeneration after Noise
Abstract
The focus of this proposal is on mechanisms and manifestations of noise-induced cochlear synaptopathy and the neurodegeneration that inevitably follows. Studies use pharmacologic and genetic approaches to probe the acute synaptic response and detailed physiologic and histologic assessment of acute and chronic consequences of the injury. Results will inform diagnosis and treatment of noise-induced injury, an issue of critical health importance to Navy personnel. Our recent work points to inner hair cell – afferent fiber synapses as the most vulnerable elements in the cochlea. In this proposal, our focus is on mechanisms and manifestations of noise-induced cochlear synaptopathy and the neurodegeneration that inevitably follows. Studies use pharmacologic and genetic approaches to probe the acute synaptic response and detailed physiologic and histologic assessment of acute and chronic consequences of the injury. Results will inform diagnosis and treatment of noise-induced injury, an issue of critical health importance to Navy personnel.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 23, 2016
- Source ID
- N000141612867
Entities
People
- Sharon Kujawa
Organizations
- Massachusetts Eye and Ear Infirmary
- Office of Naval Research
- United States Navy