Calibrated MRI Measurement of TBI Brain Integrity Quantifying Diffusion, Bleeds, Mechanics, and Structure
Abstract
This project provides a pivotal calibration technology to a network of research centers to advance MR imagingof Traumatic Brain Injury (TBI). It seeks to provide the warfighter a brain integrity diagnostic report followingaction or accident to characterize brain anatomy deciding on return to action and targeted rehabilitation of TBI wounds. It will deploy to ten labs to rigorously quantify accuracy of MRI diffusion imaging of fiber tracts,susceptibility weighted imaging of brain bleeds, MRI elastography imaging of brain mechanical strength, andstructural imaging of tissue pathologies. This will address the DoD critical goal to advance MR brain imaging and provide cross-vendor/cross-laboratory calibration of MR-based TBI pathology. It will provide a ~ground truth~ MR phantom of reference structures and fluids to quantify measurement. It will test four classes of TBI measurement: 1) diffusion measurement with micron-scale hollow fiber textiles (Taxons) in various geometries of controlled packing and crossing patterns which are designed to provide ground truth calibration of axonal loss in TBI; 2) susceptibility-weighted imaging (SWI) of microhemorrhages; 3) elastography (MRE) of tract mechanical strength or robustness to future concussions, and 4) system metrics (T1, T2, T2*, ADC) for structural imaging. The phantom quantifies MRI measurement precision in magnets ranging from 3-14T. Testing will be on a round robin basis between and across laboratories to establish the measurement precision of the top instruments worldwide at university and DoD medical centers. The labs will contrast scan results to referent measurements to advance MRI acquisition and computational analysis. It will provide a crosscalibrated set of 12 phantoms to be used in lab clusters (Baylor/Brooke, Pittsburgh/College ofLondon/T~bingen, Harvard/MGH, Stanford, Hopkins/NIH/NICoE, U Colorado/NIST, UCSD/NMCSD/Pendelton, Duke/Bragg/Lejeune, Mayo, Wayne State). It will be used at DoD military hospitals (Walter Reed/NICoE, Brooke, NMCSD) and camp hospitals (Pendleton, Bragg, Lejeune).
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 30, 2016
- Source ID
- N000141612883
Entities
People
- Elisabeth A Wilde
Organizations
- Baylor College of Medicine
- Office of Naval Research
- United States Navy