Synthetic Biology Approach to Enhancing Warfighter Tolerance to Hypothermic Stress
Abstract
The goal of this research grant is to inform strategies and develop a roadmap for a synthetic biology research program to optimize warfighter tolerance to hypothermic stress. Through knowledge capture, discussion, and strategic planning among world-class experts in the fields of gut microbiome, synthetic biology, adipose tissue storage, metabolism, and human performance in undersea and hypothermic environments, the performer will 1) Summarize current research in microbiome engineering, storage of adipose tissue, and synthetic biology approaches to optimizing metabolic control through sympathomimetic stimulation, and 2) Explore how these approaches can be leveraged by the undersea warfighter community.The proposed study has four objectives:Objective 1: Conduct relevant literature search and summarize current background and state-of-the-art in the areas of hibernation, microbiome, and metabolic control.Objective 2: Capture expert knowledge and obtain external guidance on ONR~s future strategy for incorporating synthetic biology and gut microbiome engineering methods for optimizing warfighter protection against hypothermia.Objective 3: Combine background and expert knowledge into a final detailed report. Objective 4: Create a concept map-based knowledge model of synthetic biology approaches to optimal fat storage and metabolism.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 30, 2016
- Source ID
- N000141612942
Entities
People
- Dawn Kernagis
Organizations
- Florida Institute for Human and Machine Cognition
- Office of Naval Research
- United States Navy