Real-time Analysis of Breath Biomarkers Using Selected Ion Flow Tube Mass Spectrometry for Research on the Restorative Effects of Sleep
Abstract
Military personnel routinely experience sleep loss and circadian disruption~inherent consequences of 24/7military operations -- yet this increases the risk of error and accident due to performance deficits, includingdecreased vigilance, increased errors and impaired decision making. Vulnerability to sleep deprivation andcircadian disruption differs widely between individuals; some people show severe impairments in response tosleep loss, whereas others maintain high levels of performance. Identifying which personnel are most resilient to the effects of sleep deprivation and circadian misalignment, and developing real-time biomarkers thatquantify relative impairment due to sleep deprivation or circadian misalignment, so that appropriately timed,personalized countermeasures can be deployed for those personnel at risk for performance decrements willincrease mission success. Therefore, we are requesting DURIP support for instrumentation to enhance ourhuman performance research program to develop novel methods for identifying individuals who are resilient orvulnerable to sleep deprivation and circadian disruption, and to develop biomarkers of acute and chronic sleepdeficiency and circadian disruption. The Syft T007xVoice200 ultra performs Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) and is a technology that has the ability to identify breath biomarkers accurately and reliably. Syft is sensitive (up to parts per billion), specific (~1000 known compounds), fast (sampling time <1 minute), and inexpensive (requiring only plastic straws and water to acquire a sample). This instrument will accelerate our ability to develop biomarkers for vulnerability-resilience to sleep loss, and biomarkers of sleep deficiency and circadian disruption. It will also expand training opportunities in our Division, particularlyenhancing development of new interdisciplinary projects that engage trainees and mentors in neuroscience,analytical chemistry, mathematical modeling, and statistics. Finally, this equipment request is responsive to the FY2015 National Defense Authorization Act, which specifically mentions sleep health as an important priority area for DoD.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 30, 2016
- Source ID
- N000141612965
Entities
People
- Charles Czeisler
Organizations
- Office of Naval Research
- President and Fellows of Harvard College
- United States Navy