Biophysiokinetic effect of NIR on cochlear oxidative stress and TTS
Abstract
In this project, the PI will undertake controlled experiments designed to investigate the prevention of oxidative stress induced by hypoxia and other micro environmental stressors experienced by cochlear cells with the goal to identify the optimized pretreatment to reduce or prevent temporary threshold shift (TTS) in response to noise in an animal model. To accomplish this goal, the PI will optimize the biophysical dynamics of near infrared light (NIR) exposure under physiological conditions within the inner ear, replicated in vitro in a hypoxia environmental chamber to investigate NIR protective properties against oxidative stress leading to noise induced hearing loss (NIHL), and assess, under options, the effect of NIR to reduce temporary threshold shift in an in vivo animal model. The proposed work aims to validate previous results showing the NIR suppressed inflammation and oxidative stress in cochlear hair cells.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 26, 2018
- Source ID
- N000141612966
Entities
People
- Rick Rogers
Organizations
- Office of Naval Research
- President and Fellows of Harvard College
- United States Navy