Cardiorespiratory physiology in the bottlenose dolphin before, during, and after breath-holding and restraint.
Abstract
This proposed work is intended to evaluate cardiorespiratory (heart rate, stroke volume, systemic and pulmoarterial pressures, respiratory flow and expired gas composition) function in a small cetacean, the bottlenose dolphin, at rest, during apnea, during recovery from apnea and during and following a stressful situation. In addition, we will use these data to extract medical biomarkders from animals that are adapted to a range of extreme physiological challenges (e.g. hypoxia, ischemia/reperfusion, atelectasis). These biomarkers may provide valuable information for human clinical medicine.Specific aims are: determine resting cardiac output (heart rate and stroke volume) in resting bottlenose dolphins during different phases of the respiratory cycle; systemic and pulmonary cardiac paramters (heart rate, stroke volume, mitral and tricuspid regurgitation pressures) will be measured before, during, and after trained static sequential breath-holds of up to 5 minutes; determine respiratory flow rates, expired O2 and CO2, and cardiac outuput (heart rate, stroke volume, blood pressure) before and after a "stressful" event such as physical restraint in shallow water by lifting the floor of a false bottom pool; and the transthoracic echocardiography videos collected before, during and following apneas will be used to extract biomarkers to assess cardiac morphology, displacement, enlargement, and flow characteristics.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 23, 2016
- Source ID
- N000141613088
Entities
People
- Andreas Fahlman
Organizations
- Office of Naval Research
- United States Navy