Research on HLA Typing to Support Military Contingency
Abstract
FY2015 Congressional Funds are provided to refine and expand the capabilities of the National Marrow Donor Program s (NMDP) Coordinating Center and Network sites in response to a contingency situation in which civilian or military casualties have been exposed to marrow toxic agents for the 2015 CONGRESSIONAL ADD "C.W. BILL YOUNG BONE MARROW DONOR RECRUITMENT AND RESEARCH" effort.The objective of this grant is to develop the scientific, medical and technological advances required to support military contingencies caused by injury to the hematopoietic system from toxic substances such as chemical warfare agents like ~mustard gas~ or ionizing radiation. The aim of the support is to provide matched platelets and hematopoietic progenitor cells (HPC)(e.g., bone marrow) for casualties from donors during a contingency response and support for hematopoietic progenitor cell donors from the Department of Defense. The improvements in the daily practice of transplant matching, HPC donation, and improved transplant outcome serve as an exercise to develop and demonstrate incremental improvement in the system capable of supporting casualties. To aid in the development of this rapid response capability, an integrated program of medical research will focus on aspects of transplant matching including identificationof new tissue types and the distribution of HLA types in U.S. populations, and the development of more accurate, rapid, and cost effective tissue typing technologies. The program will also focus on all aspects of rapidly providing a matched donor requested for a casualty or patient; developing search strategies for timely and optimal identification of tissue type (i.e., HLA)-matched donors; and developing matched donor selection tools and education to be used by theNational Marrow Donor Program and its network of over 350 medical and medical research organizations. A final focus is on the identification and characterization of genes other than HLA that may impact transplant outcome.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 23, 2016
- Source ID
- N000141613133
Entities
People
- Jennifer Ng
Organizations
- Georgetown University
- Office of Naval Research
- United States Navy