Precision High Intensity Training through Epigenetics (PHITE)
Abstract
PHITE Team will study the dynamics of epigenetics mechanisms during and after varying degrees of physical training. Using methyl capture technology we will profile blood and muscle biopsy samples from 10 individuals and 4 time points during HI or MOD training. This assay would focus on key gene regulatory sites and DMRs identified in a previous study of 18 human tissues. Taken together, we should be able to obtain a dynamic profile of DNA methylation during the process of intense physical activity.The data collected during HI or MOD training would serve to obtain a differential profile in methylated regions. To the best of our knowledge no other study has yet been envisaged at this scale and we hope to be able to shed light on the various molecular underpinnings of the epigenetic and regulatory aspects of gene expression. We envision creating a compendium of epigenetic markers whose methylation states are strongly associated with physical training.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 23, 2016
- Source ID
- N000141613159
Entities
People
- Timothy Broderick
Organizations
- Office of Naval Research
- United States Navy
- Wright State University