A mobile radio-telemetry system for animal physiology studies in adverse atmospheres of CO2, O2 and inert gases
Abstract
A radio-telemetry is requested for measuring multiple physiological biopotentials in a freely behaving animal model (rodents) during exposure to gaseous atmospheres that impair warfighter performance. Adverse atmospheres to be studied include sustained exposure to carbon dioxide (CO2) in air for 1-4 weeks, such as in the case of submariners while submergedand underway. Other atmospheres to be studied include hyperbaricoxygen (HBO2), hyperbaric air (hyperbaric nitrogen, HBN2), and hyperbaric heliox (HBHe), which are encountered during U.S. Navy diving operations. Planned telemetric experiments include studying the effects of chronic CO2 on sleep-wake cycle, brainstem and cortical activities, cardio-respiration (including sleepdisordered breathing), and gastric activity. In addition, measuring brain activity concurrently at multiple sites during acute exposures to HBO2 with CO2 retention will identify subcortical sites that initiate seizures during CNS oxygen toxicity (CNS-OT). Likewise, measuring brain activity simultaneously at multiple sites during exposure to HBN2 or HBHe will identify, respectively,important sites in the neurogenesis of inert gas narcosis (IGN) and high pressure neurological syndrome (HPNS). The new telemetric equipment expands the intact animal testing component of our ONR-sponsored research program and complements our ongoing in vitro neuroscience research program. Using this multi-faceted approach, our long term goal is to identify cellularmechanisms underlying CNS-OT, IGN and HPNS and to test potentially effective mitigation strategies that are neuroprotective against these disorders. Graduate students, medical students, and postdoctoral scientists who train in the P.I.???s laboratory, and visiting scientists affiliated with the DoD and ONR Undersea Medicine Program, will benefit from having access to this new mobile radio-telemetric equipment.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 26, 2018
- Source ID
- N000141712466
Entities
People
- Jay B. Dean
Organizations
- Office of Naval Research
- United States Navy
- University of South Florida