Hierarchical Nanoscale Materials Programmed using Structured DNA Nanoparticles
Abstract
Programmed self-assembly of nucleic acids into complex nanometer-scale structures offers the unique opportunity to engineer hierarch"ical, functional materials using DNA and RNA as scaffolds to organize secondary molecules including chromophores, metals, photonic e""lements, enzymes, peptides, and catalytic reactive species for diverse nanotechnology and materials applications. Target application"s of relevance to the ONR and warfighter performance include biomimetic light harvesting antennas inspired by highly efficient biolo"gical light-harvesting complexes, multienzymescaffolds to control chemical reactions for biosynthesis and biofuels, plasmonic metam""aterials, on-demand pathogen sensors, molecular computing and memory, and next generation 3D nanoscale electronic, photonic, and exc"itonic circuits for semi-conductor and otherapplications. In the next funding cycle of this research grant renewal we seek to enabl"e the large scalesynthesis of hierarchical, DNA-based materials self-assembled from DNA nanoparticle arrays realized in our previou""s funding cycle. Specifically, top-down design of arbitrary 2D and 3D structured DNA-based assemblies consisting of either infinite"" or finite extent, periodic oraperiodic structure, with nearly any symmetry conceivable will be realized. High-throughput liquidha"ndling instruments uniquely available at the Broad Institute will be leveraged to facilitate high yieldself-assembly of crystalline and semi-crystalline DNA nanoparticle arrays on the hundred microns to millimeter-scale. Algorithmic self-assembly will be used to" produce asymmetric structures programmed from the top-down using computer-aided design. Finally, we will scale upscaffold producti""on using both enzymatic and non-enzymatic, cellular production to facilitate large-scale, low-cost custom single-stranded DNA and RN"A scaffold production for use in nucleic acid based materials. Conversion of these crystalline and semi-crystalline DNA nanoparticle arrays to glass will additionally be explored to preserve their structural integrity while facilitating their integration with inor"ganic materials that are relevant to diverse applications in materials scienceincluding photonic, plasmonic, electronic, and optica""l devices, as well as nucleic acid memory archival storage.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 09, 2017
- Source ID
- N000141712609
Entities
People
- Mark Bathe
Organizations
- Massachusetts Institute of Technology
- Office of Naval Research
- United States Navy