Mitochondrial Stress and Cellular Protection in Undersea Medicine
Abstract
Two major health threats associated with undersea medicine, especially in the scenario of submariner rescue and diving related envir"onmental exposures are decompression sickness (DCS) and oxygen toxicity (O2Tox). Additional environmental stresses such as low level carbon monoxide (CO) inhalation and other potentially toxic exposures can also result from continuous long duration (months) submar"ine activities. DCS, O2Tox and other toxic exposures (e.g., COpoisoning). albeit through putatively distinct mechanisms, can ultima"tely lead to cellular dysfunction rooted in derangements of bioenergetic function. The maintenance of cellular health requires that" cellular bioenergetic capacity be preserved in the face of incipient or sustained environmental challenges. Ultimately, degradation" of normal mitochondrial function in response to environmental stressors such as DCS or O2Tox leads to cellular dysfunction and inte"gratesinto organ dysfunction such as cognitive impairment, cardiovascular instability, pulmonary insufficiency, or even death. Iden""tification of the molecular basis of pathophysiological mitochondrial responses to DCS, O2Tox and other undersea medicine related en"vironmental exposures as the bioenergetic basis of cell dysfunction enables therapeutic insights and facilitates the development of cytoprotective interventions to reduce injury resulting from such stressors.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 07, 2017
- Source ID
- N000141712643
Entities
People
- David M Eckmann
Organizations
- Office of Naval Research
- United States Navy
- University of Pennsylvania