Enhancement of Osseointegration through Invervention of Cell Signaling Network
Abstract
Enhancement of Osseointegration through Invervention of Cell Signaling NetworkTranscutaneous prosthetic implants, compared to trad""itional socket prosthetics, often suffer a higher rate of failure due to marsupilisation, avulsion, and infection. The primary reaso"n can be attributed to insufficient seal between the implant and the epidermis resulting from poor skin and soft tissue attachment to the implant. Skin and soft tissue attachment to the implant is mediated likely by a complex cell signaling network that alsomedia"tes the cell-matrix adhesion during cell proliferation, migration, and development. Understanding how cell signaling network collect"ively regulates the dynamic process of cell adhesion will lead to the development of new strategies for enhancingosseointegration through strengthening the adhesion between soft bone/tissue/skin and implants. We propose to establish a technical platform that consists of a combination of QCM-D and AFM-based nano robot for in vitro examination of cell adhesion on the implant surface. We will ut"ilize this platform to explore the feasibility of employing electrical stimulation, pharmacological intervention, and genetic interv""ention formanipulating cell adhesion. Based on the experimental data, we will construct a preliminary computational model that is c"apable of providing mechanistic insight into the regulation of cell adhesion on the implant surface.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 07, 2017
- Source ID
- N000141712648
Entities
People
- Jun Xi
Organizations
- Drexel University
- Office of Naval Research
- United States Navy