Biomarkers of Hypoxia Exposure
Abstract
AbstractGenerally, hypoxia at less than 3,048 m has no discernable effect. However, hypoxic incidents have been reported in flights"" below 3,048 m in aircrew members in unpressurized cabins and three aircrew members have been reported to have symptoms of hypoxemia"" below 1,524 m. In comparison to altitudes above 4,572 m, the onset, severity, and types of hypoxic symptoms at moderate altitude ar""e less characterized and are difficult to objectively quantify. Therefore, there is a need to determine whether a ground soldier or" an aircraft pilot has experienced significant hypoxemia after a mission at high altitude. The objective of this study is to identify reliable blood biomarkers that are quickly modified by hypoxia and that remain altered after returning to normoxia.It is expected that this study will identify blood biomarkers that are altered by an acute exposure to hypoxia that remain affected after returning to normoxia. The identification of the biomarker(s) will be useful to determine post-mission whether a ground soldier or an aircraft pilot experienced significant hypoxemia. This knowledge would assess the subject~s responses to hypoxia to then determine which individuals are at risk to experience future adverse responses to hypoxia.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 07, 2017
- Source ID
- N000141712667
Entities
People
- Laura Gonzalez Bosc
Organizations
- Office of Naval Research
- United States Navy
- University of New Mexico