Development of Medical Technology for Contingency Response to Marrow Toxic Substance
Abstract
The funds are provided for the 2016 Congressional Effort ""C.W. BILL YOUNG BONE MARROW DONOR RECRUITMENT AND RESEARCH PROGRAM"". The C". W. Bill Young Marrow Donor Recruitment and Research Program is an ongoing program to develop the science and medicine for hematopoietic transplantation from genetically matched donors unrelated to the patient coupled with development of medical contingency response capability for marrow toxic injury. The funds used for this award are FY16 Congressional funds.The National Marrow Donor Progr"am (NMDP) is pleased to submit this request for grantfunding in response to N00014-17-S-B001. With this proposal, NMDP continues to" divide thework into four inter-related focus topics as follows:A. Contingency PreparednessB. Development of Science and Technology for Rapid Identification of Matched DonorsC. Immunogenetic Studies in TransplantationD. Clinical Research in TransplantationTh"e main goal of all activities funded through this grant is to develop, test and mature the abilityof the NMDP Coordinating Center a""nd Network sites to address contingency events whereincivilian or military personnel are exposed to marrow toxic agents, primarily" ionizing radiation orchemical weapons containing nitrogen mustard. As a result of prior efforts in this regard a solidfoundation has been established. The proposed new activities will continue to enhance andexpand our capabilities in each of the four focus ar"eas. Contingency preparedness activities willcontinue to integrate NMDP~s role with federal, state and local agencies.An accident,"" a military incident, or a terrorist act in which a number of individuals are exposedto marrow toxic agents will result in injuries" from mild to lethal. But the extent of individualinjuries and the likelihood of recovery in many cases will not be apparent until" days or weeksafter the event. Casualties will be triaged by first responders, and those with major marrowinjuries who will need a"ggressive medical support and may be ultimately candidates forhematopoietic cell transplantation (HCT) will need to be identified." While these patients arebeing supported, HCT donor identification activities will be initiated because it will not beinitially cl"ear which ones may ultimately require HCT. NMDP-approved transplant centers willprovide a uniform and consistent clinical foundatio"n for receiving, evaluating and caring forcasualties. NMDP coordinating center will orchestrate the selection and testing necessary" torapidly identify the best available donor or cord blood unit for each patient utilizing its state-ofthe-art communication infra"structure, sample repository, laboratory network, and humanleukocyte antigen (HLA) expertise. NMDP~s on-going immunobiologic and cl"inical researchactivities promote studies to advance the science and technology of HCT transplantation toimprove outcome and quali"ty of life for the patients.Importantly, most individuals with near-lethal marrow toxic injuries will recover their ownmarrow func"tion provided they receive intensive supportive care from the medical professionalsthat are part of the contingency response community. These professionals can save the lives ofpersons with severe marrow suppression using the knowledge and skills practiced every day totreat patients undergoing HCT coordinated through the NMDP.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 29, 2017
- Source ID
- N000141712850
Entities
People
- Dennis L Confer
Organizations
- National Marrow Donor Program
- Office of Naval Research
- United States Navy