Multiscale Neurobiology of Brain Injury
Abstract
The long-term objective here is to link blast-induced traumatic brain injury (TBI) with multiscale, multiphysics damage evolution in" the brain using experimentally verifiable computations and simulations. The short-term goal is to conduct modeling and simulation t"o correlate blast-like mechanical trauma to structural, physiological and electrochemical damage in sub-axonal components, axons, an""d aggregates of axons in extracellular matrix. To understand the connectionbetween TBI, neuron damage and neurodegeneration, it is"" necessary to analyze neuron~s structural behavior, neuron-ECM fluid-structure interaction and electrochemistry of ions in the intra"cellular and extracellular fluidic spaces of neurons. Studies on brain injury criterion suggest that intracranial pressure below 173 kPa may not cause any brain injury whereas it has been foundexperimentally that shockwave with peak overpressure as low as 130 kPa can significantly introduce cavitation both in coup and countercoup regions with collapsing pressure of 2 MPa or higher. Simulation results also suggest that collapsing pressure due to cavitation can be as high as 20 MPa. It can be hypothesized that in the range" of 200 ~ 300 kPa peak overpressure (consideredreasonable for mTBI), complex fluid-structure interaction of the brain anatomy can l"ead to shock/bubble interactions and both symmetric and asymmetric bubble collapse can be a primary reason for structural damage. Th"e proposed computational and experimental study will determine the effect of blast-like load on protective equipment, head and the s""ubsequent electrochemical,physiological and structural damages in neurons. Since electrochemical, structural or physiological damag""e may have direct linkage with neurological disorders such as CTE, AD and PTSD, the current study will demonstrate the potential lin"kage between blast-like trauma and neurological disorders.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jan 23, 2018
- Source ID
- N000141812082
Entities
People
- Ashfaq Adnan
Organizations
- Office of Naval Research
- United States Navy
- University of Texas at Arlington