Enhancing Imaging Capability for Quantitative and Synthetic Biology Research and Education
Abstract
A major goal of synthetic biology is to develop the ability to program complex dynamics in a predictable manner in single cells and cell populations. These engineered systems can allow us to develop in-depth understanding of the design principles underlying the operation of biological systems. Further, they can serve as the foundation for developing novel technologies. Toward this goal, a major challenge is to develop the capability to design, manipulate, and quantitatively measure biological parts and devices, and cell populations in a high-throughput manner. We propose to enhance the capability of synthetic-biology and quantitative-biology research related to ongoing projects funded by different DOD agencies, particularly ONR. Specifically, we propose to request funds to purchase a Keyence all-in-one fluorescence microscope. This microscope will greatly enhance the infrastructure for high-throughput imaging of single bacterial cells or cell populations, in terms of spatial and temporal dynamics in programmed pattern formation. In addition to enhancing research in these ongoing DOD projects, the proposed instruments will also enhance related research funded by other agencies, including NSF and NIH, as well as other researchers at Duke funded by DOD. Furthermore, these instruments will enhance training experience of students and postdocs participating in DOD-funded research by exposing them to cutting-edge technologies that are not yet readily available at Duke.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 10, 2018
- Source ID
- N000141812280
Entities
People
- Lingchong You
Organizations
- Duke University
- Office of Naval Research
- United States Navy