Development of Medical Technology for Contingency Response to Marrow Toxic Substance
Abstract
The National Marrow Donor Program (NMDP) is pleased to submit this request for grant funding in response to N00014-18-S-B001. With this proposal, NMDP continues to divide the work into four inter-related focus topics as follows:A. Contingency PreparednessB. Development of Science and Technology for Rapid Identification of Matched DonorsC. Immunogenetic Studies in TransplantationD. Clinical Research in TransplantationThe main goal of all activities funded through this grant is to develop, test and mature the ability of the NMDP Coordinating Center and NMDP contracted network sites (Network sites toaddress contingency events wherein civilian or military personnel are exposed to marrow toxic agents, primarily ionizing radiation or chemical weapons containing nitrogen mustard. As a result of prior efforts in this regard a solid foundation has been established. The proposed newactivities will continue to enhance and expand our capabilities in each of the four focus areas.Contingency preparedness activities will continue to integrate NMDP???s role with federal, state and local agencies.An accident, a military incident, or a terrorist act in which a number of individuals are exposed to marrow toxic agents will result in injuries from mild to lethal. But the extent of individual injuries and the likelihood of recovery in many cases will not be apparent until days or weeks after the event. Casualties will be triaged by first responders, and those with major marrow injuries who will need aggressive medical support and may be ultimately candidates forhematopoietic cell transplantation (HCT) will need to be identified. While these patients are being supported, HCT donor identification activities will be initiated because it will not be initially clear which ones may ultimately require HCT. NMDP-approved transplant centers will provide a uniform and consistent clinical foundation for receiving, evaluating and caring for casualties. NMDP Coordinating Center will orchestrate the selection and testing necessary torapidly identify the best available donor or cord blood unit for each patient utilizing its state-of the-art communication infrastructure, sample repository, laboratory network, and human leukocyte antigen (HLA) expertise. NMDP???s on-going immunobiologic and clinical research activities promote studies to advance the science and technology of HCT transplantation toimprove outcome and quality of life for the patients. Importantly, most individuals with near-lethal marrow toxic injuries will recover their own marrow function provided they receive intensive supportive care from the medical professionalsthat are part of the contingency response community. These professionals can save the lives of persons with severe marrow suppression using the knowledge and skills practiced every day to treat patients undergoing HCT coordinated through the NMDP.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 17, 2018
- Source ID
- N000141812888
Entities
People
- Dennis L Confer
Organizations
- National Marrow Donor Program
- Office of Naval Research
- United States Navy