Feasibility of Electrodermal Activity for Detecting Seizures Elicited by Central Nervous System Oxygen Toxicity Under the Water
Abstract
Previous studies have suggested that electrodermal activity (EDA), usually measured on the fingertips, can potentially be used to predict seizures, and that EDA is sensitive to sympathetic arousal not only in dry conditions, but also when subjects are fully immersed in water. The current proposal is to examine if EDA can be used to detect and/or predict the onset of seizures caused by central nervous system oxygen toxicity (CNS-OT) in both dry and water immersion conditions.This study will provide methods for detection and/or prediction of seizures, the most adverse side effect that divers can get when pre-breathing oxygen to thwart decompression sickness (DCS). The risk of CNS-OT occurrence is highly variable between individuals, making it hard to predict the onset of seizures, and to determine the safety of exposure to HBO2. Being able to establish an individual safe level of exposure would maximize the therapeutic and operational usesof HBO2 in hyperbaric, diving, and submarine medicine (e.g. healing problematic wounds or preventing DCS) [10, 12, 18], by enabling the extension of exposure time in individuals with more neurological tolerance to HBO2. there is evidence that EDA is reactive to seizures, and that the sensitivity of EDA to sympathetic arousal is maintained under the water. This suggests that EDA could be used to detect and/or predict the onset of seizures caused by CNS-OT under the water.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 23, 2019
- Source ID
- N000141912209
Entities
People
- Ki Chon
Organizations
- Office of Naval Research
- United States Navy
- University of Connecticut