Robotic surgical and functional neural imaging systems for studying principles of sensory computation and behavior
Abstract
Robotic surgical and functional neural imaging systems for studying principles of sensory computation and behaviorRobotic surgical and functional neural imaging systems for studying principles of sensory computation and behavior. We will develop approaches to monitor functional neural responses from multiple brain circuits near simultaneously. To achieve this goal, we will use the state-of-the-art light sheet microscopy where neural tissue contained on an entire optical plane will be illuminated and imaged. This will take advantage of the genetic tools that allow labeling select neural populations with calcium indicators. Such tools are already available in fruit fly (Drosophila elanogaster) and are currently being developed in locusts (Schistocerca americana). The proposed system will enhance our current research to develop an insect-based biorobotic chemical sensing system (N00014-16-1-2426; PI: Barani Raman), and developing multimodal chemical sensor arrays (N00014-16-1-3030; PI Srikanth Singamaneni). Further, the proposed instrument will establish new research capabilities to monitor several hundreds or thousands of neurons near simultaneously and thereby allow us to probe the design and computing principles of biological olfaction. On the education front, the proposed instrument will help transfer the current emphasis on training to perform surgery to investigating fundamental problems in neuroscience and neuroengineering. Thus, it will provide more enhanced training to students and postdoctoral fellows carrying out DoD funded research and help create a highly interdisciplinary work force.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 13, 2019
- Source ID
- N000141912394
Entities
People
- Barani Raman
Organizations
- Office of Naval Research
- United States Navy
- Washington University in St. Louis