Glymphatic function in extreme environments
Abstract
This project is to carry out a study involving an analysis of blood from human subjects and comprehensive murine models testing the hypothesis that pro-inflammatory microparticles (MPs) play a causal role in glymphatic dysfunction related to Navy-diver relevant stimuli. Specific aims of this project are: (1) Assess glymphatic, CSF, and cerebral blood flow characteristics in response to operationally-relevant stressors in mice by MRI and fluorescence imaging; (2) Evaluate changes in peripheral blood neutrophil activation, sub-populations of MPs, and protein markers for neuronal integrity and function of mice engaged in Aim 1, and from humans studied by Dr. Kernagis; (3) In mice, correlate changes in glymphatic flow (Aim 1) and blood-borne changes (Aim 2) with brain and spinal cord glial activation, and with MPs and lymphocytes in deep cervical nodes that drain glymphatics.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Nov 26, 2019
- Source ID
- N000142012000
Entities
People
- Stephen R. Thom
Organizations
- Office of Naval Research
- United States Navy
- University of Maryland