Microparticles, inflammation, and decompression sickness
Abstract
This project is to carry out a study involving an analysis of blood from human subjects testing the hypothesis that circulating microparticles are the proximal cause for organ injuries following high pressure/decompression stress because they initiate an inflammatory response. Specific aims of this project are: (1) Analyze bloodborne EVs from humans engaged in high pressure exposures (open-water divers, research subjects in hyperbaric chambers, tunnel workers; (2) Evaluate differences in blood-borne inflammatory proteins among those exposed to high pressure; (3) Carry out ex vivo studies probing the biochemical mechanisms of high gas pressure-induced MPs generation by human neutrophils and platelets.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jul 20, 2020
- Source ID
- N000142012641
Entities
People
- Stephen R. Thom
Organizations
- Office of Naval Research
- United States Navy
- University of Maryland