Development of Medical Technology for Contingency Response to Marrow Toxic Substance
Abstract
Development of Medical Technology for Contingency Response to Marrow Toxic SubstanceThe National Marrow Donor Program (NMDP) is pleased to submit this request for grant funding in response to N00014-20-S-B001. With this proposal, NMDP will divide the work into four inter-related focus topics as follows:A. Contingency PreparednessB. Development of Science and Technology for Rapid Identification of Matched DonorsC. Immunogenetic Studies in TransplantationD. Clinical Research in TransplantationThe main goal of all activities funded through this grant is to develop, test and mature the ability of the NMDP Coordinating Center and NMDP contracted network sites network sites to address contingency events wherein civilian or military personnel are exposed to marrow toxic agents, primarily ionizingradiation or chemical weapons containing nitrogen mustard. As a result of prior efforts in this regard a solid foundation has been established. The proposed new activities will continue to enhance and expand our capabilities in each of the four focus areas. Contingency preparedness activities will continue tointegrate NMDPs role with federal, state and local agencies. An accident, a military incident, or a terrorist act in which a number of individuals are exposed to marrow toxic agents will result in injuries from mild to lethal. But the extent of individual injuries and the likelihood of recovery in many cases will not be apparent until days or weeks after the event. Casualties will be triaged by first responders, and those with major marrow injuries who will need aggressivemedical support and may be ultimately candidates for hematopoietic cell transplantation (HCT) will need to be identified. While these patients are being supported, HCT donor identification activities will be initiated because it will not be initially clear which ones may ultimately require HCT. NMDP-approvedtransplant centers will provide a uniform and consistent clinical foundation for receiving, evaluating and caring for casualties. NMDP Coordinating Center will orchestrate the selection and testing necessary to rapidly identify the best available donor or cord blood unit for each patient utilizing its state-of-the-artcommunication infrastructure, sample repository, laboratory network, and human leukocyte antigen (HLA) expertise. NMDPs on-going immunobiologic, bioinformatics and clinical research activities promote studies to advance the science and technology of HCT transplantation to improve outcome andquality of life for the patients. Importantly, most individuals with near-lethal marrow toxic injuries will recover their own marrow function provided they receive intensive supportive care from the medical professionals that are part ofthe contingency response community. These professionals can save the lives of persons with severe marrow suppression using the knowledge and skills practiced every day to treat patients undergoing HCT coordinated through the NMDP.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Sep 11, 2020
- Source ID
- N000142012832
Entities
People
- Steven M Devine
Organizations
- National Marrow Donor Program
- Office of Naval Research
- United States Navy