Biosensors for rapid prototyping of functional biomaterials
Abstract
Catalytic biomaterials have future applications in wearable bioelectronics. However, there remains a need to optimize the energy harvesting yields from these systems. One approach that has worked is to design biomaterials to improve substrate channeling, but the prototyping process has been hampered by slow, indirect, and low throughput functional assays. This proposal seeks to develop a platform technology to rapidly and quantitatively assess the substrate channeling properties of catalytic biomaterials. The molecular sensing platform is inspired and engineered from natural chemosensors, riboswitches, and effector proteins in bacteria. It is expected to be modular, able to function in vitro and in vivo, and easy to change the molecular target being sensed and the type of output signal. The molecular sensing system will be applied to detect in situ leakage of the intermediate malate from catalytic biomaterial prototypes, which will provide a quantitative measure of substrate channeling during bioelectrocatalysis.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 06, 2021
- Source ID
- N000142112188
Entities
People
- Ming Hammond
Organizations
- Office of Naval Research
- United States Navy
- University of Utah