Permanent magnet MRI for the development of wireless MRI-compatible devices for post-injury brain st
Abstract
Timely mitigation of brain injury for warfighters in the field has greatly suffered from the inability to perform immediate diagnost,ics with clinical-grade magnetic resonance imaging (MRI), as traditional cryogenically cooled scanners are not realistically deploye,d in the field for long term and stable operation. Emerging permanent magnet MRI systems are proven to be deployable in the field, p,ortable, require minimal maintenance, and are increasingly recruited by military research groups for the development of new monitori,ng and therapeutic methods. These emerging technologies offer a new path for immediate imaging post-injury and for more effective ti,me-critical intervention either pharmacologically or via medical device-based brain therapeutics. In order to develop more effective, brain stimulation and monitoring devices that are compatible with new permanent magnet MRI systems, preclinical research using thes,e systems in animals is a crucial steppingstone. Efforts revolve around precise quantification of the interaction between metal-base,d brain implanted devices and surrounding brain tissue at an in vivo scenario, characterization of the spatiotemporal resolution all,owed by the system for monitoring affected brain regions, and determining the device susceptibility artifacts and safety in harsh co,nditions. Over the past several years with support from the Office of Naval of Research, the PANTHER program has performed pioneerin,g research for identifying the effect of blast, blunt, cavitation and laser injuries at the cellular, sub-cellular and tissue level,scales, and is now moving towards complete volumetric optical reconstruction of physical and biological injury at higher than ever f,rame rates. Whole-brain level volumetric characterization of injury and identification of possible neuromodulation therapeutics will, greatly compliment these efforts, by coalescing the knowledge acquired at the cellular level and applying it at the systems neurosc,ience level. To complement these efforts, this PI is requesting the acquisition of a portable 1 Tesla small animal permanent magnet,MRI system. This will enable translation of MRI-compatible microelectronic intervention monitoring devices pioneered by the group, t,owards potential critical usage in injured fighters for the diagnosis and treatment brain injury immediately post insult.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Apr 01, 2022
- Source ID
- N000142212371
Entities
People
- Aviad Hai
Organizations
- Office of Naval Research
- United States Navy
- University of Wisconsin System