Neuroinflammation and glymphatic dysfunction in decompression sickness
Abstract
This research project is to evaluate the neuroinflammatory impact of high pressure and decompression using a murine model. The motiv,ation is to establish the molecular basis for neurological decompression sickness (DCS). We have found that inflammatory micropartic,les (MPs) elevated in humans, and in animal models of DCS trigger dysfunction of the brain glial-based lymphatic (aka glymphatic) sy,stem in mice. We have identified a complex pathological interaction between brain-generated MPs and systemic inflammation that may r,esolve several unexplained clinical observations. We have also identified knock-out mice resistant to DCS pathology and a pharmaceut,ical in use in humans that protects against CNS injuries. Specific Aims are: (1) Assess glymphatics function in mice by MRI and fluo,rescence microscopy; (2) Examine MPs elevations, astrocyte and microglial activation and evidence of neuroinflammation in mice; (3),Assess role of glymphatic MPs outflow in glymphatic dysfunction and neuroinflammation.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Oct 06, 2022
- Source ID
- N000142212818
Entities
People
- Stephen R. Thom
Organizations
- Office of Naval Research
- United States Navy
- University of Maryland