Linkage of Organism Level and Cellular Computational Models to Assess Pulsed RF Radiation
Abstract
LINKAGE OF ORGANISM LEVEL AND CELLULAR COMPUTATIONAL MODELS TO ASSESS PULSED RF RADIATIONProgram Officer: Tim Bentley, ONR Code 342Both wideband [electric pulses (EPs) from picosecond to millisecond duration] and narrowband (Hz to THz) electromagnetic radiation have widespread clinical and defense applications, including wound healing, microorganism inactivation, platelet activation, and nonlethal defense; however, characterizing their thermal and nonthermal biological effects from the molecular to the organism level remains challenging. Ongoing work has examined the impact of heating and membrane permeabilization for short-duration pulses and radiofrequency waves, as well as developing rapid calculations for membrane permeabilization. The proposed effort seeks to incorporate these efforts into a commercial off-the-shelf (COTS) software that models the interaction of electromagnetic radiation with an organism and the nervous system to further probe biological effects to external electromagnetic radiation. In coordination with ongoing work at the Army Research Laboratory (ARL), this effort will simulate electromagnetic stimulation of human and rat models for various waveforms and incorporate a simplified electroporation model into the neuron model to estimate effects on the nervous system. In parallel, temperature gradients will be incorporated into the asymptotic Smoluchowski equation and an analogous simplified model will be developed for incorporation into COTS software to improve the fidelity of the neuronal response at the organism level to various potential electromagnetic stimuli. The results from these studies will be examined in the context of waveforms of various parameters of interest to ARL and, as feasible, with ongoing ARL experiments. This work will provide an important extension to ongoing modeling work funded by the Office of Naval Research (ONR) and provide important conceptual understanding of in vitro work that is proposed under a separate proposal to the Army Research Office (ARO). This proposal requests $65,783.65 with a period of performance from 01MAR2023 to 29FEB2024. This abstract is publicly releasable.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 15, 2023
- Source ID
- N000142312463
Entities
People
- Allen L Garner
Organizations
- Office of Naval Research
- Purdue University
- United States Navy