Mechanisms of hyperoxia induced cell death
Abstract
Oxygen is essential to produce energy and maintenance of life. However, elevated oxygen levels (hyperoxia) have detrimental effects leading to cell death and tissue damage. The mechanisms of hyperoxia-mediated cell death are complex, cell type#specific, and are still not fully characterized. Previous studies have established the role of increased oxidative stress and the involvement of both apoptotic and non-apoptotic signaling in mediating hyperoxia-induced cell death. However, the systematic characterization of the cell death processes involved in hyperoxia is still lacking. We hypothesize that oxygen is a crucial regulator of cell death signaling pathways. To test this hypothesis, we will undertake two complementary experimental approaches. First, we will focus on testing which known cell death signaling processes are crucial in promoting hyperoxia induced cell death using both chemical and genetic inhibitors of known cell death promoting processes. Second, we will undertake unbiased genomic approaches, whereby the genes that are essential for hyperoxia-induced cell death will be discovered. This research will address a key issue of great relevance to the Navy by establishing the precise cellular mechanisms regulating hyperoxia induced cell death. These findings will further enable the development of new therapeutic or preventive modalities aimed at mitigating the cytotoxic effects of hyperoxia.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Jun 29, 2023
- Source ID
- N000142312465
Entities
People
- Peter Tsvetkov
Organizations
- Office of Naval Research
- United States Navy