DURIP Repair Mechanisms of Oxidative Tissue Damage
Abstract
For well over a century, we have known that breathing oxygen at increased atmospheric pressure is toxic to the lungs and central nervous system. Learned more recently, oxygen breathing also affects skeletal muscle function and leads to impaired work performance. A past and present goal of the USN is to extend diving operations at greater depths, safely. Understanding pathological mechanisms of oxygen toxicity is critical for achieving this goal. The purpose of this proposal is to procure a next generation confocal laser scanning microscope that will allow for innovative research directed at measuring oxidative tissue damage and repair mechanisms. The proposed microscope system will be used for research and as an instructional tool for students, residents and fellows. The microscope will define abnormalities in tissue/cellular structure and function caused by oxygen breathing. The proposed instrumentation will strengthen current research projects funded by the ONR and will support research-related education of many young scientists who are enthusiastic in advancing a Department of Defense topic area.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- Mar 15, 2024
- Source ID
- N000142412250
Entities
People
- Heath G Gasier
Organizations
- Duke University
- Office of Naval Research
- United States Navy