DURIP A High-Framerate Optical Imaging System for Brain Tissue Dynamics Inspection Under Transient Energy Exposure
Abstract
(PUBLICLY RELEASABLE) Warfighters in the field can get exposed to all kinds of energy, such as mechanical impact, microwave and heat, containing temporal variations spanning orders of magnitudes of timescales. The absorption of the energy leads to tissue responses such as mechanical deformation, thermal deformation, and even physiological change such as protein coagulation. More accurate characterization of tissue s physical and thermal properties under energy exposure with various spatial and temporal distributions is critical to the development of injury prevention and treatment technologies or field-deployable medical applications of interest to the Navy. The PI is requesting the acquisition of a high-framerate optical imaging system composed of a high-speed camera capable of working at greater than 1 million frame per second (fps), and a high signal-to-noise-ratio microscope. The optical imaging system will be integrated with a micro-second pulsed microwave exposure system to allow the observation and recording of the tissue deformation with a greater than 500 kHz framerate, thus enable high-framerate and high-resolution study of the brain tissue thermoelastic dynamics under transient microwave exposure. Over the past several years with support from the Office of Naval of Research, the PANTHER program has performed pioneering research for identifying the formation and effect of different kinds of brain injuries, such as blast, blunt, cavitation, and laser injuries, as well as developing structured materials for injury protection. The proposed acquisition will not only be critical for facilitating the research progress stemming from the PI s group, but also pave the way towards research in collaboration with other PANTHER PIs to understand and treat brain injury. The proposed high-framerate, high-sensitivity optical imaging system will benefit PANTHER research about microcavitation and its mechanism to cause brain injury. The proposed opticalsystem can also be integrated with MRI to obtain multi-physics information of the brain tissue, and to infer high-spatiotemporal-resolution temperature profile in brain tissue in real time, which is challenging in conventional MRI. Moreover, the proposed optical system will benefit the PANTHER effort in experimental investigation of structured materials for impact protection. It can be integrated with existing experimental facilities such as laser-enabled microballistics, direct macroscale impact testing, vibration testing, and quasi-static compression and tension testing apparatuses, thus will enable high spatiotemporal resolution observation and analysis of the structural deformation under impact and wave incidence.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 15, 2024
- Source ID
- N000142412312
Entities
People
- Chu Ma
Organizations
- Office of Naval Research
- United States Navy
- University of Wisconsin System