DURIP Multi-Purpose Evaluation Platform for Critical Care Monitoring and Control Systems
Abstract
This proposal concerns the development of a versatile multi-purpose evaluation platform suited to both in vivo and hardware-in-the-loop simulation (HILS)-based testing of complex multi-variable physiological monitoring and closed-loop control systems relevant to automated critical care and combat casualty care. Such a platform has received an increasing interest, with promising recent developments. However, prior effort dedicated to the development of an evaluation platform is generally rare, and there is no evaluation platform available that can facilitate the development and deployment of next-generation complex multi-variable physiological monitoring and closed-loop control algorithms and systems. Most prior in vivo evaluation was conducted in non-standardized laboratory settings with a large degree of heterogeneity in experimental setup and acquired data, which are often not similar to real-world critical care/combat casualty care situations. In addition, they are not ideally suited to the holistic monitoring of patient physiology to assess the influence of automated treatments on the collective patient physiology. Prior HILS-based evaluation effort does not practically exist due to the serious lack of knowledge and availability of a widely accepted methodology. Furthermore, the requirement fora credible evaluation platform is becoming more and more stringent: as physiological closed-loop control systems evolve into sophisticated multi-variable entities, the evaluation platforms are required to be equipped with highly sophisticated multi-modal sensing and actuation capabilities. These gaps strongly necessitate the development of a multi-purpose equipment system that can enable in vivo and HILS-based evaluation of next-generation closed-loop controlled automated treatments. This proposal intends to fill these gaps by implementing an equipment system capable of in vivo and HILS-based evaluation of a wide range of physiological monitoring and closed-loop control algorithms and systems especially relevant to critical care and combat casualty care, including, but not limitedto: fluid resuscitation, mechanical ventilation, and IV drug administration (sedatives, opioids, and vasopressors). Our proposed platform is designed and configured to be able to conduct both in vivo and HILS-based evaluations of a wide range of aspects pertaining to critical care/combat casualty care automation. The proposed equipment system will significantly enhance the quality of our ongoing as well as proposed research projects and their related workforce development activities sponsored by DoD, extend our research capability to HILS and in vivo space, and synergistically integrate into our existing equipment and devices relevant to the development and evaluation of automated critical care/combat casualty care.
Document Details
- Document Type
- DoD Grant Award
- Publication Date
- May 15, 2024
- Source ID
- N000142412326
Entities
People
- Jin-Oh Hahn
Organizations
- Office of Naval Research
- United States Navy
- University of Maryland